On March 9th, 1997 Biggie was killed over a disagreement stemming from an interpretation of the lyrics to this song. No one is sure whether or not this song actually references the then recent shooting of Tupac in a New York recording studio, but that soon became besides the point as it kicked off a chain of nasty events which sadly culminated in both their deaths. It's total bullshit, that should never have happened.
Notorious B.I.G-Who Shot Ya?
This is can be found off of Mister Cee's definitive collection of BIggie songs found over here